Dr. Cassander Titley-O’Neal’s research interests include understanding the fate and transport of pollutants in the marine environment and their effect(s) on marine organisms living there.  For her PhD., she studied the fate of tributyltin (TBT), a once popular biocide in antifouling paint, in Canada and her native home, the British Virgin Islands.  TBT is known to bioaccumulate in molluscs and has been cited as the primary causative agent for imposex.  Imposex is one of of the masculinized effects caused by TBT and other organotins on gonochoristic female gastropods, where the female genital system is conserved, but is superimposed with male characteristics (i.e. vas deferens and/or penis).  Below are some of her publications:

Gene expression profiling in the ovary of queen conch (Strombus gigas) exposed to environments with high tributyltin in the British Virgin Islands.

Cassander P. Titley-O’Neal, Daniel J. Spade, Yanping Zhano, Rosalinda Kan, Christopher J. Martyniuk, Nancy D. Denslow and Bruce A. MacDonald. (2013). Gene expression profiling in the ovary of queen conch (Strombus gigas) exposed to environments with high tributyltin in the British Virgin Islands.  Science of the Total Environment. 449: 52 – 62.

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The effects of organotins on female gastropods.

Cassander P. Titley-O’Neal, Kelly. R. Munkittrick and Bruce A. MacDonald. (2011). The effects of organotins on female gastropods.  Journal of Environmental Monitoring13: 2360 – 2388.

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The relationship between imposex and tributyltin (TBT) concentration in Strombus gigas from the British Virgin Islands.

Cassander P. Titley-O’Neal, Bruce A. MacDonald, Émilien Pelletier, Richard Saint-Louis and Orville S. Phillip. The relationship between imposex and tributyltin (TBT) concentration in Strombus gigas from the British Virgin Islands. (2011).  Bulletin of Marine Science. 87 (3): 421 – 435.

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Using Nucella lapillus (L.), as a Bioindicator of Tributyltin (TBT) Pollution in Eastern Canada: A Historical Perspective.

Cassander P. Titley-O’Neal, Bruce A. MacDonald, Émilien Pelletier, Richard Saint-Louis. (2011) Using Nucella lapillus (L.), as a Bioindicator of Tributyltin (TBT) Pollution in Eastern Canada: A Historical Perspective. (2011).  Water Quality Research Journal of Canada. 46: 74 – 86.

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